J. Deveryshetty

Cryo-EM captures the coordination of long-range allostery and asymmetric electron transfer by a bi-copper cluster in the nitrogenase-like DPOR complex

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

Homodecameric Rad52 promotes single-position Rad51 nucleation in homologous recombination

This study reveals that homodecameric Rad52 facilitates single-position Rad51 nucleation in homologous recombination through specific structural and interaction features.

Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins

This study shows Rtt105 binds to RPA, staples it, and blocks RIP interactions without ssDNA, while stabilizing RPA-ssDNA filaments with ssDNA.

Novel strand exchange activity of the human PALB2 DNA Binding Domain and its critical role for DNA repair in cells

The paper identifies a DNA-binding domain in PALB2 that enhances RAD51-mediated DNA repair and can promote strand exchange independently of RAD51.