R. A. Friedman

An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

This study uses engineered human cardiac tissues to show how SLE autoantibodies affect myocardial injury through distinct binding patterns and functional effects on cardiac cells.

A pancreatic cancer mouse model with human immunity

This paper introduces a mouse model of metastatic human pancreatic cancer infiltrated by human immune cells to study tumor immune microenvironment and treatment responses.

Intestinal myofibroblasts regulate intestinal epithelial cell plasticity via YAP/TAZ

This study shows that intestinal myofibroblasts enhance enteroid self-renewal and survival through YAP/TAZ signaling and TGF-β, without involving Wnt.

Targeting MEK5 impairs non-homologous end-joining repair and sensitizes prostate cancer to DNA damaging agents

This study shows that targeting MEK5 impairs NHEJ repair and enhances sensitivity of prostate cancer to DNA-damaging agents in vitro and in vivo.

Genome-wide Association Study for Noise-induced Cochlear Synaptopathy.

This paper conducts a GWAS on the Hybrid Mouse Diversity Panel to identify genetic loci associated with noise-induced cochlear synaptopathy and identifies 4 novel loci and candidate genes.