Removal of the catalytic subunit of DNA-protein kinase in the proximal tubules promotes DNA and tubular damage during kidney injury
Mallory Swanson, J. Yun, Daniel Mohr Collier, Lavanya Challagundla, Murat Doğan, Cem Kuscu, M. R. Garrett, Kevin R. Regner, J. H. Chung, Frank Park
This study shows that DNA-PKcs in proximal tubules reduces DNA damage during acute kidney injury but not chronic injury, with mixed effects on fibrosis.
bioRxiv · Aug 22, 2024 · PreprintPhysiology