Author

J. J. Babon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

N. J. Kershaw· 3 shared E. Leong· 2 shared K. Doggett· 2 shared S. E. Nicholson· 2 shared W. S. Alexander· 2 shared A. Chuah· 1 shared A. J. Kueh· 1 shared A. Kueh· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

N. J. Kershaw

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Author profile →

3 papers

Recent·Most cited

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

Y. Zhang, R. Morris, A. M. D. Lorenzo, X. Meng, N. J. Kershaw, P. Kiridena, G. J. Brown, G. Burgio, J. Y. Cappello, Q. Shen, H. Wang, C. M. Turnbull, T. Lea-Henry, M. Stanley, Z. Yu, , J. I. Ellyard

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

bioRxiv · Apr 27, 2023 · PreprintImmunology

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo

K. Doggett, N. Keating, F. Dehkhoda, G. M. Bidgood, E. Leong, A. Kueh, N. A. Nicola, N. J. Kershaw, J. J. Babon, W. S. Alexander, S. E. Nicholson

This study shows that both the KIR and SH2 domains of SOCS1 are essential for its function in suppressing cytokine signaling, as mutations in either domain lead to neonatal lethality and inflammation.

bioRxiv · Dec 20, 2022 · PreprintCell Biology

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

K. Li, L. M. Guzman, L. Whitehead, E. Leong, A. J. Kueh, W. S. Alexander, N. J. Kershaw, J. J. Babon, K. Doggett, S. E. Nicholson

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

bioRxiv · Jul 17, 2022Cell Biology