Author

K. Doggett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. Whitehead· 3 shared E. Leong· 2 shared J. J. Babon· 2 shared J. K. Heath· 2 shared K. J. Morgan· 2 shared N. J. Kershaw· 2 shared S. E. Nicholson· 2 shared T. E. Hall· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

L. Whitehead

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo

K. Doggett, N. Keating, F. Dehkhoda, G. M. Bidgood, E. Leong, A. Kueh, N. A. Nicola, N. J. Kershaw, J. J. Babon, W. S. Alexander, S. E. Nicholson

This study shows that both the KIR and SH2 domains of SOCS1 are essential for its function in suppressing cytokine signaling, as mutations in either domain lead to neonatal lethality and inflammation.

bioRxiv · Dec 20, 2022 · PreprintCell Biology

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

K. Li, L. M. Guzman, L. Whitehead, E. Leong, A. J. Kueh, W. S. Alexander, N. J. Kershaw, J. J. Babon, K. Doggett, S. E. Nicholson

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

bioRxiv · Jul 17, 2022Cell Biology

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

K. Doggett, K. J. Morgan, S. Mieruszynski, B. B. Williams, A. M. Olthof, A. L. Garnham, M. J. G. Milevskiy, L. Whitehead, J. Coates, M. Buchert, R. J. O'Donoghue, T. E. Hall, Z. Gong, T. L. Putoczki, M. Ernst, , J. K. Heath

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

bioRxiv · Dec 9, 2021Cancer Biology

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

K. J. Morgan, K. Doggett, F.-S. Geng, L. Whitehead, K. A. Smith, B. M. Hogan, C. Simons, G. J. Baillie, R. Molania, A. T. Papenfuss, T. E. Hall, E. A. Ober, D. Y. R. Stainier, Z. Gong, J. K. Heath

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

bioRxiv · Aug 25, 2021Cancer Biology