Author

S. E. Nicholson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Leong· 2 shared J. J. Babon· 2 shared K. Doggett· 2 shared N. J. Kershaw· 2 shared W. S. Alexander· 2 shared A. J. Kueh· 1 shared A. Kueh· 1 shared A. M. Lew· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

E. Leong

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo

K. Doggett, N. Keating, F. Dehkhoda, G. M. Bidgood, E. Leong, A. Kueh, N. A. Nicola, N. J. Kershaw, J. J. Babon, W. S. Alexander, S. E. Nicholson

This study shows that both the KIR and SH2 domains of SOCS1 are essential for its function in suppressing cytokine signaling, as mutations in either domain lead to neonatal lethality and inflammation.

bioRxiv · Dec 20, 2022 · PreprintCell Biology

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

K. Li, L. M. Guzman, L. Whitehead, E. Leong, A. J. Kueh, W. S. Alexander, N. J. Kershaw, J. J. Babon, K. Doggett, S. E. Nicholson

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

bioRxiv · Jul 17, 2022Cell Biology

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

s. zhang, J. Rautela, N. G. Bediaga, T. Kolesnik, Y. You, L. Dagley, J. Bedo, H. Wang, L. Sun, R. Sutherland, E. Surgenor, N. Iannarella, R. S. Allan, F. Souza-Fonseca-Guimaraes, Y. Xie, , Y. Zhan

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

bioRxiv · Mar 31, 2022 · PreprintImmunology