Author

N.-Y. Zheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. Li· 6 shared M. Huang· 6 shared P. C. Wilson· 6 shared S. Changrob· 5 shared J. J. Guthmiller· 4 shared C. T. Stamper· 3 shared F. Krammer· 3 shared H. L. Dugan· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

L. Li

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6 papers

Recent·Most cited

Mutability and hypermutation antagonize immunoglobulin codon optimality

J. J. McGrath, J. Park, C. A. Troxell, J. C. Chervin, L. Li, J. R. Kent, S. Changrob, Y. Fu, M. Huang, N.-Y. Zheng, G. D. Wilbanks, S. A. Nelson, J. Sun, G. Inghirami, M. L. L. Madariaga, , P. C. Wilson

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

bioRxiv · Mar 13, 2024Immunology

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

S. Changrob, P. J. Halfmann, H. Liu, J. L. Torres, J. J. C. McGrath, G. Ozorowski, L. Li, M. Kuroda, T. Maemura, M. Huang, D. G. Wilbanks, N.-Y. Zheng, H. L. Turner, S. A. Erickson, Y. Fu, , P. C. Wilson

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

bioRxiv · Oct 31, 2022Immunology

Librator, a platform for optimized sequence editing, design, and expression of influenza virus proteins

L. Li, O. Stovicek, J. J. Guthmiller, S. Changrob, Y. Fu, H. L. Dugan, C. T. Stamper, N.-Y. Zheng, M. Huang, P. C. Wilson

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

bioRxiv · Apr 29, 2021 · PreprintMicrobiology

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines

J. J. Guthmiller, H. A. Utset, C. Henry, L. Li, N.-Y. Zheng, W. Sun, M. C. Vieira, S. Zost, M. Huang, S. E. Hensley, S. Cobey, P. Palese, P. C. Wilson

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

bioRxiv · Mar 16, 2021Immunology

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

J. J. Guthmiller, J. Han, H. A. Utset, L. Li, L. Y.-L. Lan, C. Henry, C. T. Stamper, O. Stovicek, L. Gentles, H. L. Dugan, N.-Y. Zheng, S. T. Richey, M. E. Tepora, D. J. Bitar, S. Changrob, , P. C. Wilson

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

bioRxiv · Feb 25, 2021 · PreprintImmunology

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

J. J. Guthmiller, O. Stovicek, J. Wang, S. Changrob, L. Li, P. Halfmann, N.-Y. Zheng, H. Utset, C. T. Stamper, H. L. Dugan, W. D. Miller, M. Huang, Y.-N. Dai, C. A. Nelson, P. D. Hall, , P. C. Wilson

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

bioRxiv · Sep 12, 2020Immunology