Author

M. M. Taketo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Jumaa· 2 shared J. Jellusova· 2 shared A. Hayashi· 1 shared A. Kikuchi· 1 shared A. Niida· 1 shared B.-C. Chen· 1 shared C. Setz· 1 shared D. Fonseca-Arce· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

H. Jumaa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

K. N. Cosgun, H. Jumaa, M. E. Robinson, X. Liang, G. Xiao, L. N. Chan, J. Lee, K. Kume, E. Leveille, D. Fonseca-Arce, D. Khanduja, H. L. Ng, N. Feldhahn, J. Song, W. C. Chan, , M. Mueschen

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

Accumulation of the GSK3 target protein β-catenin is lethal for B cell precursors and malignant B cells

H. Jumaa, K. M. Kistner, C. Setz, M. M. Taketo, H. Jumaa, J. Jellusova

This study shows that β-catenin accumulation caused by GSK3 inhibition leads to reduced survival in B cell precursors and malignant B cells.

bioRxiv · Sep 17, 2021 · PreprintImmunology

Fine-tuning of β-catenin in thymic epithelial cells is required for postnatal T cell development

S. Fujimori, I. Ohigashi, H. Abe, M. M. Taketo, Y. Takahama, S. Takada

This study investigates the role of β-catenin in thymic epithelial cells during postnatal T cell development, showing that its expression must be finely tuned to support proper thymus function.

bioRxiv · May 2, 2021Immunology

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

Y. Kawasaki, T. Hamaji, K. Owada, A. Hayashi, Y. Wu, T. Nogi, M. Okada, S. Sakai, N. Tokushige, S. Sasagawa, H. Nakagawa, Y. Kouyama, A. Niida, K. Mimori, T. Kuroda, , Y. Mimori-Kiyosue

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

bioRxiv · Sep 18, 2020 · PreprintCell Biology