Author

J. K. Heath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

K. Doggett· 2 shared K. J. Morgan· 2 shared L. Whitehead· 2 shared T. E. Hall· 2 shared Z. Gong· 2 shared A. L. Garnham· 1 shared A. M. Olthof· 1 shared A. T. Papenfuss· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

K. Doggett

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Author profile →

2 papers

Recent·Most cited

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

K. Doggett, K. J. Morgan, S. Mieruszynski, B. B. Williams, A. M. Olthof, A. L. Garnham, M. J. G. Milevskiy, L. Whitehead, J. Coates, M. Buchert, R. J. O'Donoghue, T. E. Hall, Z. Gong, T. L. Putoczki, M. Ernst, , J. K. Heath

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

bioRxiv · Dec 9, 2021Cancer Biology

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

K. J. Morgan, K. Doggett, F.-S. Geng, L. Whitehead, K. A. Smith, B. M. Hogan, C. Simons, G. J. Baillie, R. Molania, A. T. Papenfuss, T. E. Hall, E. A. Ober, D. Y. R. Stainier, Z. Gong, J. K. Heath

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

bioRxiv · Aug 25, 2021Cancer Biology