T. E. Hall

Flexing fish: cell surface plasticity in response to shape change in the whole organism

The paper develops an active trapping model to study caveolae's role in maintaining sarcolemmal integrity during shape changes in zebrafish.

A role for caveolar proteins in regulation of the circadian clock

This study shows that cavin proteins modulate the circadian clock by interacting with PER2 and responding to stimuli like oxidative stress and calcium influx.

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

Caveolae respond to acute oxidative stress through membrane lipid peroxidation, cytosolic release of CAVIN1, and downstream regulation of NRF2

This study shows that caveolae regulate oxidative stress response by lipid peroxidation, CAVIN1 release, and NRF2 interaction, affecting cell death and regeneration.

In vivo proteomic mapping through GFP-directed proximity dependent biotin labelling in zebrafish

The paper introduces a method to map protein interactions in zebrafish using GFP-directed biotin labelling and applies it to study caveolin interactors in muscle cells.

Genes derived from ancient polyploidy have higher genetic diversity and are associated with domestication in Brassica rapa

The paper identifies candidate genes associated with domestication in Brassica rapa and finds that genes from ancient polyploidy are more diverse and linked to domestication.

APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy

APEX-Gold converts APEX reaction products into silver/gold particles for improved EM detection of tagged proteins.

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

An Endocytic Capture Model for Skeletal Muscle T-tubule Formation

This study develops a four-dimensional model of T-tubule formation in zebrafish using live imaging and electron microscopy, proposing an endocytic capture mechanism involving dynamic endocytic tubules, myofibrils, and membrane delivery from recycling endosomes and Golgi.

Stony coral populations are more sensitive tochanges in vital rates in disturbed environments

The paper examines how chronic environmental stressors and disturbance regimes affect coral population dynamics and cover using a structured population model.