J. K. Williams

Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-Associated Virus Production

This study evolves MAAP variants to enhance AAV production, finding that selected variants improve vector genome packaging in multiple AAV serotypes.

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

Tannic Acid Inhibits α-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain

This study shows tannic acid inhibits α-synuclein fibril formation by binding to its N-terminal domain, with pH dependence observed through NMR, AFM, and ThT assays.

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition

This study identifies a potent SARS-CoV-2 antibody, 54042-4, that neutralizes variants of concern and has a unique epitope and genetic structure.

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

The paper identifies public antibody clonotypes in SARS-CoV-2 convalescents and vaccinated individuals, revealing common epitope recognition and potential vaccine efficacy mechanisms.

Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain

This paper uses molecular dynamics simulations to analyze the conformational flexibility of the SARS-CoV-2 RBD Loop 3 and identifies new unbound substates that could be therapeutic targets.

NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils

This paper identifies an N-terminal binding interface on acetylated-α-synuclein monomers that interacts with fibrils and off-pathway oligomers, revealing a mechanism for fibril elongation and potential therapeutic targets.