J. E. Parker

Oligomerisation of a plant helper NLR requires cell-surface and intracellular immune receptor activation

This study shows that helper NLR NRG1 forms oligomeric complexes with EDS1 and SAG101 at the plasma membrane upon co-activation of intracellular and cell surface receptors.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

Differential requirement for the EDS1 catalytic triad in A. thaliana and N. benthamiana

The paper investigates the functional differences of EDS1 catalytic triad in Arabidopsis and Nicotiana benthamiana, finding lineage-specific roles in TNL immunity and PRR signaling.

XopQ induced stromule formation in Nicotiana benthamiana is causally linked to ETI signaling and depends on ADR1 and NRG1

The paper investigates whether XopQ-induced stromule formation is linked to ETI signaling or programmed cell death in N. benthamiana and finds it is connected to ETI signaling but not cell death.

Differential EDS1 requirement for cell death activities of plant TIR-domain proteins

The paper identifies four conserved TIR groups in land plants, two of which are EDS1-dependent and two are EDS1-independent in cell death activities.

In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris

The paper identifies a mutation in the ERG6 gene as the first mechanism of amphotericin B resistance in Candida auris, observed during in vivo treatment.

Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity

This study identifies TPR1's role in mitigating immune-related physiological damage in Arabidopsis by analyzing its chromatin binding and effects on gene expression and plant growth.

The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants

This study identifies SRF3 as a receptor kinase that coordinates iron homeostasis and immune responses in plants by regulating callose synthase activity.

The fungal root endophyte Serendipita vermifera displays inter-kingdom synergistic beneficial effects with the microbiota in Arabidopsis thaliana and barley

This study shows that the fungal endophyte Serendipita vermifera synergizes with bacterial microbiota to protect Arabidopsis and barley from pathogens, with benefits dependent on host and microbiota composition.

Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity

The paper identifies two distinct modules, NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4, required for TNL receptor immunity, showing effector recognition-dependent associations and functional requirements.

Arabidopsis cell surface LRR immune receptor signaling through the EDS1-PAD4-ADR1 node

This study identifies the EDS1-PAD4-ADR1 node as a convergence point for immune signaling in Arabidopsis, linking surface and intracellular LRR receptors.

Pattern recognition receptors confer plant salt tolerance via WRKY18/WRKY40 transcription factors

This study identifies a mechanism by which pattern recognition receptors (PRRs) in Arabidopsis thaliana confer salt tolerance through WRKY18/WRKY40 transcription factors.

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility

The paper identifies HaRxL21, an oomycete effector, and shows it interacts with TPL to suppress plant immunity and promote pathogen susceptibility.

Genome-wide chromatin binding of transcriptional corepressor Topless-related 1 in Arabidopsis

The paper identifies genome-wide chromatin binding sites of TPR1 in Arabidopsis using ChIP-seq and finds it binds genes involved in immunity and growth.

Arabidopsis ENHANCED DISEASE RESISTANCE1 Protein Kinase Regulates the Association of ENHANCED DISEASE SUSCEPTIBILITY1 and PHYTOALEXIN DEFICIENT4 to Inhibit Cell Death

This study identifies a mutation in PAD4 that enhances resistance and cell death in Arabidopsis, revealing EDR1's role in regulating the EDS1-PAD4 complex to control defense responses.

Arabidopsis thaliana natural variation in temperature-modulated immunity uncovers transcription factor UNE12 as a thermoresponsive regulator

The paper identifies UNE12 as a temperature-responsive regulator of salicylic acid immunity in Arabidopsis thaliana using natural variation and genetic analysis.

Arabidopsis PAD4 lipase-like domain is a minimal functional unit in resistance to green peach aphid

The paper shows that the N-terminal PAD4-lipase-like domain in Arabidopsis limits Green Peach Aphid infestation but not pathogen immunity, suggesting the C-terminal domain is needed for immune functions and EDS1 interaction.

Plant mixed lineage kinase domain-like proteins limit biotrophic pathogen growth

The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

The paper identifies a coevolved EDS1-SAG101-NRG1 module essential for TIR-domain immune receptor-mediated cell death signaling in plants.