Author

J. Prudhomme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

K. G. Le Roch· 3 shared S. Abel· 3 shared T. Hollin· 3 shared T. Lenz· 3 shared A. Saraf· 2 shared A.-L. Banuls· 2 shared C. Banks· 2 shared L. Florens· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

K. G. Le Roch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Sand flies and Toscana virus: intra-vector infection dynamics and impact on Phlebotomus perniciosus life-history traits

L. Laroche, A.-L. Banuls, R. Charrel, A. Fontaine, N. Ayhan, J. Prudhomme

This study investigates TOSV infection dynamics in Phlebotomus perniciosus sand flies and finds it affects their life history traits, including hatching time and extrinsic incubation period.

bioRxiv · Feb 25, 2024 · PreprintMicrobiology

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Z. M. Chahine, M. Gupta, T. Lenz, T. Hollin, S. Abel, C. Banks, A. Saraf, J. Prudhomme, S. Bhanvadia, L. Florens, K. G. Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

bioRxiv · Sep 11, 2023Microbiology

Establishment and maintenance of two sand fly colonies (Phlebotomus perniciosus and Phlebotomus papatasi) to implement experimental infections

J. Prudhomme, L. Laroche, A. Nguyen Hoang Quan, J. Fournier, I. Mhaidi, A. Berhard, M. Killick-Kendrick, A.-L. Banuls

This study establishes and maintains sand fly colonies for Phlebotomus perniciosus and Phlebotomus papatasi, achieving stable weekly production of 800 and 400 individuals, respectively, within one year.

bioRxiv · Jul 19, 2023 · PreprintEcology

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. P. Maher, M. A. Bakowski, A. Vantaux, E. L. Flannery, C. Andolina, M. Gupta, Y. Antonova-Koch, M. Argomaniz, C.-M. Monica, C. Brice, A. T. Chao, A. K. Chatterjee, W. T. Cheng, E. Chuenchob, C. A. Cooper, , McNama

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

G. Batugedara, X. M. Lu, S. Abel, Z. Chahine, B. Hristov, D. Williams, T. Hollin, T. Wang, A. Cort, T. Lenz, T. Thompson, J. Prudhomme, A. K. Tripathi, G. Xu, J. Cudini, , K. G. Le Roch

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology