Author

J. Sacharz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

R. Ghai· 3 shared B. Collins· 2 shared C. McConville· 2 shared D. A. Stroud· 2 shared K.-E. Chen· 2 shared M. Chilton· 2 shared M. Healy· 2 shared R. J. Hall· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

R. Ghai

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Author profile →

4 papers

Recent·Most cited

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

M. Healy, K. McNally, R. Butkovic, M. Chilton, K. Kato, J. Sacharz, C. McConville, E. Moody, S. Shaw, V. Planelles-Herrero, S. Yadav, J. Ross, U. Borucu, C. Palmer, K.-E. Chen, , P. Cullen

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

M. D. Healy, J. Sacharz, K. E. McNally, C. McConville, V. Tillu, R. J. Hall, M. Chilton, P. J. Cullen, M. Mobli, R. Ghai, D. A. Stroud, B. Collins

The paper identifies the structural basis of the interaction between SNX17 and PDLIM family proteins, revealing a specific PDZ binding motif and unique electrostatic contacts.

bioRxiv · Jul 29, 2021Biochemistry

Getting more out of FLAG-Tag co-immunoprecipitation mass spectrometry experiments using FAIMS.

C.-S. Ang, J. Sacharz, M. G. Leeming, S. Nie, S. Varshney, N. E. Scott, N. A. Williamson

This study shows that using FAIMS in FLAG-Tag co-immunoprecipitation improves protein coverage by reducing tag peptide interference in mass spectrometry.

bioRxiv · Jun 15, 2021Biochemistry

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

K.-E. Chen, Q. Guo, T. A. Hill, Y. Cui, A. K. Kendall, Z. Yang, R. J. Hall, M. Healy, J. Sacharz, S. J. Norwood, S. Fonseka, B. Xie, R. C. Reid, N. Leneva, R. G. Parton, , B. M. Collins

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

bioRxiv · Dec 3, 2020 · PreprintBiochemistry