P. J. Cullen

Mechanism and regulation of cargo entry into the Commander recycling pathway

The paper identifies the mechanism by which SNX17 cargo is selected for entry into the Commander recycling pathway through direct binding to the Retriever sub-complex.

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

This study defines how FAM21 couples SNX27-Retromer to the WASH complex through motif-based interactions essential for endosomal recycling.

Plasma Activated Water as a Pre-Treatment Strategy in the Context of Biofilm-Infected Chronic Wounds

This study evaluates Plasma Activated Water (PAW) as a pre-treatment to enhance antiseptic efficacy against biofilms in chronic wounds.

Five inhibitory receptors display distinct vesicular distributions in T cells

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

Ecological Inducers of the Yeast Filamentous Growth Pathway Reveal Environment-Dependent Roles for Pathway Components

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in Yeast

This study identifies new regulatory features of the Cdc42-Ste20 module in yeast MAPK signaling, including Ste20p turnover and a Ste20p-independent pathway branch.

An effective sanitizer for fresh produce production: In situ plasma activated water treatment inactivates pathogenic bacteria and maintains the quality of cucurbit fruit

This paper demonstrates that plasma activated water (PAW) effectively reduces pathogenic bacteria on cucurbit fruits while maintaining quality and shelf life, outperforming sodium hypochlorite in some aspects.

CHC22 clathrin functions in the early secretory pathway by two-site interaction with SNX5 and p115

This paper identifies two distinct interaction sites in CHC22 that mediate its recruitment to ERGIC membranes, enabling GLUT4 transport bypassing the Golgi.

Exploring the Regulation of Cdc42 Stability and Turnover in Yeast

This paper identifies high temperature-induced degradation of yeast Cdc42p via ubiquitin ligase and chaperones, revealing a tradeoff between mating sensitivity and cellular fitness.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.

This study identifies the molecular mechanism by which SNX27-Retromer interacts with ESCPE-1 to facilitate endosomal cargo recycling, revealing a conserved surface interaction and evolutionary pathway.

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

The paper identifies the structural basis of the interaction between SNX17 and PDLIM family proteins, revealing a specific PDZ binding motif and unique electrostatic contacts.

The Antimicrobial Efficacy Of Plasma Activated Water Is Modulated By Reactor Design And Water Composition

This study evaluates how reactor design and water composition affect the antimicrobial efficacy of plasma activated water (PAW), finding that DBDD-PAW is more effective than BSD-PAW in reducing bacterial load.

Turnover Regulation of the Rho GTPase Cdc42 by Heat Shock Protein Chaperones and the MAPK Pathway Scaffold Bem4

This paper shows that the yeast Rho GTPase Cdc42p is turned over by HSPs and the E3 ligase Rsp5p, with implications for cell polarity and MAPK pathway specificity.

Platinum nanoparticles inhibit intracellular ROS generation and protect against Cold Atmospheric Plasma-induced cytotoxicity

This study shows platinum nanoparticles reduce intracellular reactive oxygen species and protect cells from cold atmospheric plasma-induced cytotoxicity in both cancerous and non-cancerous cell lines.

Synergistic Cytotoxicity Between Cold Atmospheric Plasma and Pyrazolopyrimidinones Against Glioblastoma Cells

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1 (CTR1/SLC31A1)

This study shows that retromer-dependent recycling of CTR1 maintains copper homeostasis and influences platinum drug sensitivity.

Cold Atmospheric Plasma induces silver nanoparticle uptake, oxidative dissolution and enhanced cytotoxicity in Glioblastoma multiforme cells

This study shows that combining cold atmospheric plasma with silver nanoparticles significantly increases cytotoxicity in glioblastoma cells through enhanced nanoparticle uptake and oxidative stress.

Acute perturbation of retromer and ESCPE-1 leads to functionally distinct and temporally resolved defects in endosomal cargo sorting.

This study uses acute perturbation to investigate retromer and ESCPE-1 roles in endosomal cargo sorting, revealing distinct temporal defects in GLUT1 and CI-MPR sorting.

Low dose Cold Atmospheric Plasma induces membrane oxidation, stimulates endocytosis and enhances uptake of nanomaterials in Glioblastoma multiforme cells

Regulation of Bud Emergence by a MAPK Pathway

This study shows the MAPK pathway regulates bud emergence in yeast under nutrient-limiting conditions by modulating Cdc42p activity and polarity targets.

Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include Regulators of the Actin Cytoskeleton

The paper identifies proteins interacting with the yeast mucin Msb2p, revealing its role in connecting signaling to actin cytoskeleton regulation and other cellular processes.