Author

J. A. Burger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:flow cytometry· 2 Organism:non-human primate· 2 Assay:protein structure· 2

Frequent Co-Authors

R. W. Sanders· 7 shared A. B. Ward· 6 shared K. Sliepen· 6 shared M. Poniman· 6 shared M. Claireaux· 5 shared M. J. van Gils· 5 shared G. Kerster· 4 shared I. Bontjer· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

R. W. Sanders

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses

P. J. M. Brouwer, H. R. Perrett, T. Beaumont, H. Nijhuis, S. Kruijer, J. A. Burger, W.-H. Lee, H. Muller-Krauter, R. W. Sanders, T. Strecker, M. J. van Gils, A. B. Ward

This study identifies neutralizing antibody epitopes against Lassa virus GPC using electron microscopy, revealing challenges in vaccine-induced responses and opportunities for improved vaccine design.

bioRxiv · Dec 21, 2023Immunology

Deep profiling of antigen-specific B cells from different pathogens identifies novel compartments in the IgG memory B cell and antibody-secreting cell lineages

M. Claireaux, G. Elias, G. Kerster, L. H. Kuijper, M. C. Duurland, A. G. Paul, J. A. Burger, M. Poniman, W. Olijhoek, N. de Jong, R. de Jongh, E. Wynberg, H. D. van Willigen, M. Prins, G. J. de Bree, , S. M. van Ham

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.

bioRxiv · Dec 19, 2023 · PreprintImmunology

Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines

I. del Moral-Sanchez, E. G. Wee, Y. Xian, W.-H. Lee, J. D. Allen, A. Torrents de la Pena, R. d. P. F. Rocha, J. Ferguson, A. N. Leon, S. Koekkoek, E. E. Schermer, J. A. Burger, S. Kumar, R. Zwolsman, M. Brinkkemper, , R. W. Sanders

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

bioRxiv · Aug 27, 2023Microbiology

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

D. Guerra, T. Beaumont, L. Radic, G. Kerster, K. van der Straten, M. Yuan, J. L. Torres, W.-H. Lee, H. Liu, M. Poniman, I. Bontjer, J. A. Burger, M. Claireaux, T. G. Caniels, J. L. Snitselaar, , M. J. van Gils

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

bioRxiv · Oct 14, 2022Immunology

Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

H. R. Perrett, P. J. M. Brouwer, J. Hurtado, M. L. Newby, J. A. Burger, L. Liu, J. H. Bouhuijs, G. Gibson, T. Messmer, J. S. Schieffelin, A. Antanasijevic, G.-J. Boons, M. Crispin, R. W. Sanders, B. Briney, A. B. Ward

The paper structures and characterizes Lassa virus glycoproteins from multiple lineages and identifies neutralizing antibodies that target conserved epitopes.

bioRxiv · Sep 26, 2022Immunology

Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

P. J. M. Brouwer, A. Antanasijevic, A. J. Ronk, H. Mulller-Krauter, Y. Watanabe, M. Claireaux, N. M. Lloyd, T. P. L. Bijl, H. R. Perrett, T. H. Steijaert, J. A. Burger, M. M. van Haaren, K. Sliepen, M. van Gils, M. Crispin, , R. W. Sanders

This study develops Lassa virus glycoprotein nanoparticles that stabilize GPC trimers and elicit neutralizing antibodies targeting a new vulnerability site.

bioRxiv · Mar 28, 2022 · PreprintImmunology

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast, J. Han, D. Guerra, G. Kerster, B. D. van Schaik, A. Jongejan, A. I. Schriek, M. Grobben, P. J. Brouwer, K. van der Straten, Y. Aldon, J. Capella-Pujol, J. L. Snitselaar, , M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

bioRxiv · Dec 1, 2021Immunology

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

G. Sulbaran, P. Maisonnasse, A. Amen, D. Guilligay, N. Bosquet, J. A. Burger, M. Poniman, M. Buisson, S. D. Dylon, T. Naninck, J. Lemaitre, W. Gros, A.-S. Gallouet, R. Marlin, C. Bouillier, , W. Weissenhorn

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

bioRxiv · Jul 26, 2021Immunology

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

P. J. M. Brouwer, M. Brinkkemper, P. Maisonnasse, N. Dereuddre-Bosquet, M. Grobben, M. Claireaux, M. de Gast, R. Marlin, V. Chesnais, S. Diry, J. D. Allen, Y. Watanabe, J. M. Griezen, G. Kerster, H. L. Turner, , de Bree

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

bioRxiv · Nov 7, 2020Immunology