Author

M. Poniman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2 Organism:non-human primate· 2

Frequent Co-Authors

J. A. Burger· 6 shared K. Sliepen· 5 shared M. J. van Gils· 5 shared R. W. Sanders· 5 shared A. B. Ward· 4 shared G. J. de Bree· 4 shared G. Kerster· 4 shared I. Bontjer· 4 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

J. A. Burger

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

D. Guerra, L. Radic, M. Brinkkemper, M. Poniman, L. van der Maas, J. L. Torres, A. B. Ward, K. Sliepen, J. Schinkel, R. W. Sanders, M. J. van Gils, T. Beaumont

This study develops bispecific antibodies that target conserved regions on the SARS-CoV-2 spike protein, showing improved neutralization breadth against multiple sarbecovirus strains.

bioRxiv · May 9, 2024Microbiology

Deep profiling of antigen-specific B cells from different pathogens identifies novel compartments in the IgG memory B cell and antibody-secreting cell lineages

M. Claireaux, G. Elias, G. Kerster, L. H. Kuijper, M. C. Duurland, A. G. Paul, J. A. Burger, M. Poniman, W. Olijhoek, N. de Jong, R. de Jongh, E. Wynberg, H. D. van Willigen, M. Prins, G. J. de Bree, , S. M. van Ham

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.

bioRxiv · Dec 19, 2023 · PreprintImmunology

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

D. Guerra, T. Beaumont, L. Radic, G. Kerster, K. van der Straten, M. Yuan, J. L. Torres, W.-H. Lee, H. Liu, M. Poniman, I. Bontjer, J. A. Burger, M. Claireaux, T. G. Caniels, J. L. Snitselaar, , M. J. van Gils

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

bioRxiv · Oct 14, 2022Immunology

IgG1 responses following SARS-CoV-2 infection are polyclonal and highly personalized, whereby each donor and each clone displays a distinct pattern of cross-reactivity against SARS-CoV-2 variants

D. M. H. van Rijswijck, A. Bondt, M. Hoek, K. van der Straten, T. G. Caniels, M. Poniman, D. Eggink, C. B. E. M. Reusken, G. J. de Bree, R. W. Sanders, M. van Gils, A. J. R. Heck

The paper analyzes IgG1 clonal responses to SARS-CoV-2 variants in infected donors, finding unique and polyclonal antibody repertoires with varying cross-reactivity across variants.

bioRxiv · Feb 24, 2022Immunology

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast, J. Han, D. Guerra, G. Kerster, B. D. van Schaik, A. Jongejan, A. I. Schriek, M. Grobben, P. J. Brouwer, K. van der Straten, Y. Aldon, J. Capella-Pujol, J. L. Snitselaar, , M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

bioRxiv · Dec 1, 2021Immunology

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

G. Sulbaran, P. Maisonnasse, A. Amen, D. Guilligay, N. Bosquet, J. A. Burger, M. Poniman, M. Buisson, S. D. Dylon, T. Naninck, J. Lemaitre, W. Gros, A.-S. Gallouet, R. Marlin, C. Bouillier, , W. Weissenhorn

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

bioRxiv · Jul 26, 2021Immunology

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

P. J. M. Brouwer, M. Brinkkemper, P. Maisonnasse, N. Dereuddre-Bosquet, M. Grobben, M. Claireaux, M. de Gast, R. Marlin, V. Chesnais, S. Diry, J. D. Allen, Y. Watanabe, J. M. Griezen, G. Kerster, H. L. Turner, , de Bree

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

bioRxiv · Nov 7, 2020Immunology