The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

bioRxiv · Dec 18, 2022Pharmacology & Toxicology

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

bioRxiv · Jan 25, 2022 · PreprintImmunology

Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomas

E. Larson, A. L. Ellis, M. A. Rodgers, A. J. Balgeman, R. V. Moriarty, C. Ameel, T. Baranowski, J. Tomko, C. Causgrove, P. Maiello, S. L. OConnor, C. A. Scanga

This study shows that pre-existing SIV infection alters T cell phenotypes and reduces TNF responses during early Mtb co-infection, impairing immune control.

bioRxiv · Dec 14, 2020Immunology