Author

H. P. Gideon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:non-human primate· 5 Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. L. Flynn· 5 shared H. J. Borish· 3 shared P. L. Lin· 3 shared P. Maiello· 3 shared S. M. Fortune· 3 shared A. K. Shalek· 2 shared C. Scanga· 2 shared F. H. Hopkins· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

J. L. Flynn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CD4+ T cells are homeostatic regulators during Mtb reinfection

J. Bromley, S. K. C. Ganchua, S. K. Nyquist, P. Maiello, M. Chao, H. J. Borish, M. Rodgers, J. Tomko, K. Kracinovsky, D. Mugahid, S. N. Nguyen, D. Wang, J. M. Rosenberg, E. C. Klein, H. P. Gideon, , J. L. Flynn

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

E. B. Irvine, A. O'Neil, P. A. Darrah, S. Shin, A. Choudhary, W. Li, W. Honnen, S. Mehra, D. Kaushal, H. P. Gideon, J. L. Flynn, M. Roederer, R. A. Seder, A. Pinter, S. Fortune, G. Alter

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Nature Immunology · Nov 22, 2021Peer-reviewedImmunology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

T. Wessler, L. R. Joslyn, H. J. Borish, H. P. Gideon, J. L. Flynn, D. E. Kirschner, J. J. Linderman

This paper develops a computational model to simulate Mtb infection in lungs and identifies factors that prevent bacterial dissemination.

bioRxiv · Jul 24, 2019Immunology

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

J. L. Flynn, A. M. Cadena, F. H. Hopkins, P. Maiello, A. F. Carey, E. A. Wong, C. J. Martin, H. P. Gideon, R. M. DiFazio, P. Andersen, P. L. Lin, S. M. Fortune

This study shows that concurrent M. tuberculosis infection in macaques provides strong protection against secondary infection.

bioRxiv · Aug 29, 2018Microbiology