Author

E. A. McMillan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

K. E. Hamilton· 3 shared C. H. Danan· 2 shared K. A. Whelan· 2 shared K. E. Naughton· 2 shared K. Katada· 2 shared L. R. Parham· 2 shared M. A. White· 2 shared X. Ma· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

K. E. Hamilton

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Author profile →

5 papers

Recent·Most cited

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

M. Sasaki, T. Hara, J. X. Wang, Y. Zhou, K. V. Kennedy, N. N. Umeweni, M. A. Alston, Z. C. Spergel, R. Nakagawa, E. A. McMillan, K. A. Whelan, T. A. Karakasheva, K. E. Hamilton, M. A. Ruffner, A. B. Muir

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2024Peer-reviewedCell Biology

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

C. H. Danan, K. E. Naughton, K. E. Hayer, S. Vellapan, E. A. McMillan, Y. Zhou, R. Matsuda, S. K. Nettleford, K. Katada, L. R. Parham, X. Ma, A. Chowdhury, B. J. Wilkins, P. Shah, M. D. Weitzman, K. E. Hamilton

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

bioRxiv · Apr 6, 2023 · PreprintCell Biology

High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling

J. B. MacMillan, R. G. Linington, S. K. Hight, R. S. Lokey, W. Bray, K. Kurita, A. Shaikh, J. Haeckl, S. La, A. Lohith, E. A. McMillan, M. A. White, T. N. Clark, J. Lee, F. Carnevale, , S. Wei

This paper introduces a platform integrating phenotypic screening and metabolomics to improve mechanism of action prediction for natural products, leading to the discovery of novel bioactive compounds.

bioRxiv · Jun 8, 2022Pharmacology & Toxicology

IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B

L. R. Parham, P. A. Williams, P. Chatterji, K. Acheampong, C. H. Danan, K. Katada, X. Ma, L. A. Simon, K. E. Naughton, R. Mizuno, T. Karakasheva, E. A. McMillan, K. A. Whelan, D. C. Brady, S. M. Shaffer, K. E. Hamilton

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.

bioRxiv · Feb 28, 2022 · PreprintCell Biology

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

P.-H. CHEN, L. Cai, C. Yang, J. Kim, B. Faubert, L. Boroughs, B. Ko, J. Sudderth, E. A. McMillan, L. Girard, M. Peyton, K. Huffman, M. D. Shields, D. Shames, H. S. Kim, , R. J. DeBerardinis

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

bioRxiv · Mar 11, 2019Cancer Biology