SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes
H. T. T. Ha, X. T. A. Nguyen, L. K. Vo, N. C. P. Leong, S. Liu, D. T. Nguyen, Y. P. Lim, J. Y. Wu, T. Q. Nguyen, J. Oh, M. R. Wenk, A. Cazenave-Gassiot, Y. W. Ong, L. N. Nguyen
This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.
bioRxiv · Dec 14, 2022 · PreprintBiochemistry