Author

N. H. Roy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. K. Burkhardt· 2 shared A. Buffone· 1 shared B. Huang· 1 shared D. A. Hammer· 1 shared D. Blumenthal· 1 shared E. Fazeli· 1 shared E. Sanchez· 1 shared G. Follain· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

J. K. Burkhardt

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Author profile →

4 papers

Recent·Most cited

Mechanically active integrins direct cytotoxic secretion at the immune synapse

M. S. Wang, Y. Hu, E. Sanchez, X. Xie, N. H. Roy, M. De Jesus, W. Jin, J. H. Lee, Y. Hong, M. Kim, L. C. Kam, K. Salaita, M. Huse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

bioRxiv · Oct 2, 2021 · PreprintImmunology

Automated cell tracking using StarDist and TrackMate

E. Fazeli, N. H. Roy, G. Follain, R. F. Laine, L. von Chamier, P. Hänninen, J. E. H. Eriksson, J.-Y. Tinevez, G. Jacquemet

This paper presents an automated cell tracking pipeline using StarDist and TrackMate for 2D live-cell imaging, applicable to fluorescent and brightfield images without coding knowledge.

bioRxiv · Sep 22, 2020Cell Biology

LFA-1 signals to promote actin polymerization and upstream migration in T cells

N. H. Roy, S. H. Kim, A. Buffone, D. Blumenthal, B. Huang, S. Agarwal, P. L. Schwartzberg, D. A. Hammer, J. K. Burkhardt

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

bioRxiv · Apr 29, 2020Cell Biology

CrkL is required for donor T cell migration to GvHD Target organs

N. H. Roy, M. Mammadli, J. K. Burkhardt, M. Karimi

This study identifies CrkL as essential for donor T cell migration to GvHD target organs, showing that CrkL-deficient T cells cannot migrate into inflamed tissues but can still eliminate hematopoietic tumors.

bioRxiv · Nov 25, 2019Immunology