Author

James Morris

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Systems Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Christopher G. SmithiD· 3 shared Dineika ChandranandaiD· 3 shared Florent C. MouliereiD· 3 shared Nitzan RosenfeldiD· 3 shared Alexandra BeckiD· 2 shared Caitlin HalliD· 2 shared Davina Gillian GaleiD· 2 shared Elizabeth K. MooreiD· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenomics

Christopher G. SmithORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilities

Emanuel Gonçalves, Rebecca C. Poulos, Zhaoxiang Cai, Syd Barthorpe, Srikanth Srinivas Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer M.S. Koh, Howard W. Lightfoot, Sadia Mahboob, Iman D. Mali, , Roger R. Reddel

The paper presents a pan-cancer proteomic map of 949 cell lines, revealing protein-specific biomarkers of cancer vulnerabilities and showing proteomic data's superior predictive power for drug response.

Cancer Cell · Jul 14, 2022Peer-reviewedSystems Biology

Refined characterization of circulating tumor DNA through biological feature integration

Havell Markus, Dineika Chandrananda, Elizabeth K. Moore, Florent C. Mouliere, James Morris, James D. Brenton, Christopher G. Smith, Nitzan Rosenfeld

This study identifies and integrates three genome-wide features of cfDNA fragmentation to enhance ctDNA detection in ovarian cancer patients.

Scientific Reports · Feb 4, 2022Peer-reviewedGenetic & Genomic Medicine

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew S. Barthorpe, Howard W. Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, , Mathew J. Garnett

This study integrates drug sensitivity data with CRISPR screens to identify drug mechanisms and biomarkers for cancer therapy.

Molecular Systems Biology · Jul 1, 2020Peer-reviewedSystems Biology

Integrated clonal analysis reveals circulating tumor DNA in urine and plasma of glioma patients

Florent C. Mouliere, Katrin Heider, Christopher G. Smith, Jing Su, Mareike K. Thompson, James Morris, Jonathan C. M. Wan, Dineika Chandrananda, James Hadfield, Marta Grezlak, Irena Hudecova, Wendy N. Cooper, Davina Gillian Gale, Matthew Eldridge, Colin Watts, , Richard James Mair

The paper detects circulating tumor DNA in plasma and urine of glioma patients using sequencing guided by tumor mutations.

bioRxiv · Sep 11, 2019 · PreprintGenomics

Selecting Short DNA Fragments In Plasma Improves Detection Of Circulating Tumour DNA

Florent C. Mouliere, Anna Piskorz, Dineika Chandrananda, Elizabeth K. Moore, James Morris, Christopher G. Smith, Teodora Goranova, Katrin Heider, Richard James Mair, Anna Maria Supernat, Ioannis Gounaris, Susana R�os, Jonathan C. M. Wan, Mercedes Jimenez‐Liñan, Davina Gillian Gale, , Nitzan Rosenfeld

The paper shows that selecting short DNA fragments in plasma improves the detection of circulating tumour DNA by enriching mutated DNA, enabling identification of copy number alterations previously undetected.

bioRxiv · May 5, 2017 · PreprintGenomics