Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation
Luís Miguel Monteiro, Patrícia R. Pitrez, Simão Correia-Santos, Nicola Dark, Deolinda R. Santinha, Célia Alexandra Aveleira, Megan Townsend, James Taylor, Xavier Nissan, Vilma A. Sardão, Luísa Cortes, Richard Mitter, Antonio Marino, Carlos Sousa-Soares, Rui Ribeiro, , Lino Ferreira
This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.
bioRxiv · Jun 27, 2025 · PreprintCell Biology