Author

Megan Townsend

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:imputation· 1

Frequent Co-Authors

Alessandro Ori‬‬iD· 1 shared Alicia R. MartiniD· 1 shared Andreia Sofia BernardoiD· 1 shared Antonio MarinoiD· 1 shared Benjamin M. NealeiD· 1 shared Carlos Sousa-SoaresiD· 1 shared Célia Alexandra AveleiraiD· 1 shared Christine R. StevensiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Alessandro Ori‬‬ORCID

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2 papers

Recent·Most cited

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

Luís Miguel Monteiro, Patrícia R. Pitrez, Simão Correia-Santos, Nicola Dark, Deolinda R. Santinha, Célia Alexandra Aveleira, Megan Townsend, James Taylor, Xavier Nissan, Vilma A. Sardão, Luísa Cortes, Richard Mitter, Antonio Marino, Carlos Sousa-Soares, Rui Ribeiro, , Lino Ferreira

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

bioRxiv · Jun 27, 2025 · PreprintCell Biology

Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays

Matthew T. DeFelice, Jonna Grimsby, Daniel P. Howrigan, Kai Yuan, Sinéad B. Chapman, Christine R. Stevens, Samuel DeLuca, Megan Townsend, Joseph D. Buxbaum, Margaret Ann Pericak‐Vance, Shengying Qin, Dan Joseph Stein, Solomon Teferra, Ramnik J. Xavier, Hailiang Huang, , Benjamin M. Neale

The paper introduces a cost-efficient sequencing method called Blended Genome Exome (BGE) that combines low-coverage whole genome and high-coverage exome data, achieving >99% concordance with 30x WGS for variant imputation and rare coding variant calling.

bioRxiv · Apr 3, 2024 · PreprintGenomics