Demian Park

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue

The paper introduces ExRPath and 15ExMPath techniques to expand human brain tissue for nanostructure analysis, revealing amyloid nanoclusters associated with SARS-CoV-2 in COVID-19 patients.

Screening channelrhodopsins using robotic intracellularelectrophysiology and single cell sequencing

The paper introduces a method combining robotic electrophysiology and single-cell sequencing to link opsin sequences to their functional properties, demonstrating its efficiency over manual methods.

In Vivo Optical Clearing of Mammalian Brain

This study shows that modifying the optical properties of a mammalian brain can enhance deep imaging without affecting native physiology.

Recording of cellular physiological histories along optically readable self-assembling protein chains

The paper introduces a method to record cellular physiological histories using self-assembling protein chains that can be optically read, demonstrating its use in neurons and mouse brain.

Rapid Directed Molecular Evolution of Fluorescent Proteins in Mammalian Cells

This paper describes a method for rapidly optimizing fluorescent proteins in mammalian cells, resulting in enhanced near-infrared fluorescent proteins with improved intracellular brightness and multicolor imaging capabilities.

Population imaging of neural activity in awake behaving mice in multiple brain regions

The paper introduces a new genetically encoded voltage indicator, SomArchon, enabling high-speed, sensitive neural activity imaging in awake mice across multiple brain regions.

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

The paper introduces PRISM, a method for multiplexed imaging of synaptic proteins, enabling high-throughput quantification of co-expression and nanometer-scale organization.