Minghong Ma

This study investigates how TRPML1 regulates lysosome positioning and actin-membrane linkers in astrocyte processes, influencing synaptic contacts.

The paper identifies an oxytocinergic circuit from the paraventricular hypothalamus to the medial olfactory tubercle that drives prosocial grooming in mice by inhibiting mOT neurons via OXTR and GIRK channels.

This paper uses an iPSC model of BLBS to show that the H3.3 L48R variant disrupts chromatin dynamics, neuronal differentiation, and electrophysiological function.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

This study identifies heightened LC-NE neuron activity and altered connectivity as causes of sleep fragmentation and memory deficits in a 16p11.2 deletion ASD mouse model.

The paper identifies two genetically distinct BLA pathways to the ventral striatum that bidirectionally modulate negative emotional states through projection-specific mechanisms.

This study shows dopamine in the ventral striatum initiates sniffing by modulating respiratory rate and neuronal activity.

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

This study investigates the distinct roles of Aβ low-threshold mechanoreceptors in mechanical pain transmission, finding they have both local and global functions in hyperalgesia.

Scratch-AID automatically detects and quantifies mouse scratching behavior with high accuracy, outperforming manual methods in various itch models and drug screening applications.

This study characterizes olfactory neuronal cells from nasal biopsies using single-cell and bulk RNA sequencing, showing their neuronal similarity and utility in brain disorder research.

This study identifies a prefrontal-olfactory network involved in olfactory selective attention, showing coordinated activity in mPFC and olfactory regions during attention shifts.

The paper shows that self-grooming in mice increases social attraction through chemosensory cues, using optogenetic induction of grooming behavior.

This study shows that aversive learning increases the release probability of olfactory sensory neurons in mice, correlating with freezing behavior during fear retrieval.

This study uses high-speed videography and machine learning to objectively assess mouse pain state through paw withdrawal reflex parameters.

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.

The paper uses genetic tracing in mice to show that nociceptors in different body regions have distinct central arbor structures, which may explain the high spatial acuity for pain in the limbs.