Author

John E. P. Syka

Thermo Fisher Scientific (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Joshua D. HinkleiD· 2 shared Carla KirschbaumiD· 1 shared Carol V. RobinsoniD· 1 shared Christopher Mullen· 1 shared Corinne A. LutomskiiD· 1 shared Frances I Butroid· 1 shared Graeme C. McAlisteriD· 1 shared Haigang SongiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

Joshua D. HinkleORCID

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Author profile →

2 papers

Recent·Most cited

Defining state-selective lipid binding to brain GPCRs - introducing REVEAL

Sophie A. S. Lawrence, Carla Kirschbaum, Corinne A. Lutomski, Haigang Song, Joshua D. Hinkle, Frances I Butroid, Rafael Donadelli Melani, John E. P. Syka, Christopher Mullen, Tarick J. El‐Baba, Carol V. Robinson

The paper introduces REVEAL, a mass spectrometry method to identify receptor-specific lipid binding in mammalian membrane proteins, showing agonism alters lipid occupancy and plasmalogen lipids are depleted under oxidative stress.

bioRxiv · May 5, 2026 · PreprintBiophysics

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated Ion-Tandem Mass Tags (AI-TMT)

Trenton M. Peters-Clarke, Yiran Liang, Keaton L. Mertz, Kenneth W. Lee, Michael S. Westphall, Joshua D. Hinkle, Graeme C. McAlister, John E. P. Syka, R. T. Kelly, Joshua J. Coon

This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.

Journal of Proteome Research · May 7, 2024Peer-reviewedBiochemistry