Author

John J. Nicol

Eterna Massive Open Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Christian A. ChoeiD· 2 shared Eterna ParticipantsiD· 2 shared Hannah K. Wayment-SteeleiD· 2 shared Rhiju DasiD· 2 shared Roger Wellington-OguriiD· 2 shared Wipapat KladwangiD· 2 shared Adele XuiD· 1 shared Alicia SolórzanoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Christian A. ChoeORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Compact RNA sensors for increasingly complex functions of multiple inputs

Christian A. Choe, Johan O. L. Andreasson, Feriel Mélaïne, Wipapat Kladwang, Michelle J. Wu, Fernando Portela, Roger Wellington-Oguri, John J. Nicol, Hannah K. Wayment-Steele, Michael R. Gotrik, Eterna Participants, Purvesh Khatri, William James Greenleaf, Rhiju Das

The paper designs compact RNA sensors for complex functions of multiple inputs using crowdsourced designs and an algorithm, achieving applications like tuberculosis diagnosis.

Nature Chemistry · Nov 12, 2025Peer-reviewedSynthetic Biology

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang, Hannah K. Wayment-Steele, Craig H. Kerr, Adele Xu, Do Soon Kim, Ved V. Topkar, Christian A. Choe, Daphna Rothschild, Gerald C. Tiu, Roger Wellington-Oguri, Kotaro Fujii, Eesha Sharma, Andrew M. Watkins, , Rhiju Das

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.

Nature Communications · Mar 22, 2022Peer-reviewedMolecular Biology