Author

Jonna Heldrich

New York University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Andreas HochwageniD· 4 shared Luís A. Vale-SilvaiD· 3 shared Tovah E. MarkowitziD· 3 shared Adhithi R. Raghavan· 2 shared Xiaoji SuniD· 2 shared Agnès ThierryiD· 1 shared Allison F. MoyeriD· 1 shared Andrew D’Avino· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenomics

Andreas HochwagenORCID

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4 papers

Recent·Most cited

Crossover designation recruits condensin to reorganize the meiotic chromosome axis

Victor A. Leon, Tovah E. Markowitz, Soogil Hong, Adhithi R. Raghavan, Jonna Heldrich, Keun Pil Kim, Andreas Hochwagen

This study identifies condensin as a regulator of meiotic chromosome axis remodeling near crossover sites in yeast, showing it promotes cohesin removal and affects chromosome segregation.

Current Biology · Sep 1, 2025Peer-reviewedGenomics

Synthetic chromosome fusion: effects on genome structure and function

Jingchuan Luo, Luís A. Vale-Silva, Adhithi R. Raghavan, Guillaume Mercy, Jonna Heldrich, Xiaoji Sun, Mingyu Kenneth Li, Weimin Zhang, Neta Agmon, Kun Yang, Jitong Cai, Giovanni Stracquadanio, Agnès Thierry, Yu Zhao, Camila Coelho, , Jef D. Boeke

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.

bioRxiv · Aug 10, 2023 · PreprintSynthetic Biology

Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae

Jonna Heldrich, Carolyn R. Milano, Tovah E. Markowitz, Sarah N. Ur, Luís A. Vale-Silva, Kevin D. Corbett, Andreas Hochwagen

The paper identifies two pathways for meiotic chromosome axis assembly in yeast, showing cohesin-dependent and cohesin-independent mechanisms recruit axis proteins to genomic regions with high gene density.

Nucleic Acids Research · Mar 25, 2022Peer-reviewedGenomics

Topoisomerases modulate the timing of meiotic DNA breakage and chromosome morphogenesis in Saccharomyces cerevisiae

Jonna Heldrich, Xiaoji Sun, Luís A. Vale-Silva, Tovah E. Markowitz, Andreas Hochwagen

This study investigates the roles of topoisomerases I and II in meiotic DNA breakage and chromosome remodeling in yeast, showing distinct effects of their disruption on DSB timing and chromosome structure.

Genetics · Mar 9, 2020Peer-reviewedGenomics