Melissa S. Jurica

This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.

This study investigates how the branchpoint-interacting stem loop (BSL) structure in U2 snRNA affects splicing efficiency and gene expression by altering branchpoint recognition and U2 snRNP biogenesis.

The paper studies how different introns respond to splicing inhibitors in a humanized yeast strain, revealing intron-specific sensitivity and the impact of BP sequence variation.

This study investigates DHX15's role in A-complex spliceosome disassembly, showing its involvement in quality control and ATP-dependent rearrangements during splicing.

The paper investigates how SF3A and SF3B proteins affect U2 snRNA structure and how SF3B inhibitors impact spliceosome assembly.

The paper identifies features of herboxidiene that mediate conformation-dependent SF3B1 interactions and inhibit splicing by interacting with SF3B1 sidechains.

The paper introduces a two-step chemical probing method using tandem mass-spectrometry to assess lysine reactivity in macromolecular complexes, showing it reflects structural models of ribosomes and spliceosomes.