Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Aakriti Jain, Isaac P. Heremans, Gilles Rademaker, Tyler C. Detomasi, Peter J. Rohweder, Dashiell Anderson, Justin Zhang, Grace A. Hernandez, Suprit Gupta, Teresa von Linde, Mike Lange, Martina Spacci, Jiayi Luo, Y. Rose Citron, James A. Olzmann, , Roberto Zoncu
The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.
Science · Mar 27, 2025Peer-reviewedBiochemistry