Author

K. B. Margulies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Diwan· 2 shared A. Javaheri· 2 shared A. Kovacs· 2 shared D. R. Rawnsley· 2 shared K. Bedi· 2 shared K. Hyrc· 2 shared X. Ma· 2 shared A. A. Desai· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

A. Diwan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension

V. Jani, M. I. Aslam, A. J. Fenwick, W. Ma, H. Gong, G. Milburn, D. Nissen, I. M. Cubero Salazar, O. Hanselman, M. Mukherjee, M. K. Halushka, K. B. Margulies, K. Campbell, T. C. Irving, D. A. Kass, S. Hsu

This study identifies contractile deficits in right ventricular myocytes of HFrEF-PH patients, showing reduced calcium-activated tension and altered myosin ATP turnover, with implications for targeted therapies.

bioRxiv · Mar 9, 2023Biophysics

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

K. Sikder, E. Phillips, Z. Zhong, N. Wang, J. Saunders, D. Mothy, A. Kossenkov, T. Schneider, Z. Nichtova, G. Csordas, K. B. Margulies, J. C. Choi

This study identifies perinuclear stress responses from nuclear envelope deterioration as contributors to LMNA cardiomyopathy using a mouse model and translatome profiling.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

Tissue- and sex-specific DNA damage tracks aging in rodents and humans

A. Guilbaud, F. Ghanegolmohammadi, Y. Wang, J. Leng, A. Kreymerman, J. Gamboa Varela, J. Garbern, H. Elwell, F. Cao, E. M. Ricci-Blair, C. Liang, S. Balamkundu, C. Vidoudez, M. S. DeMott, K. Bedi, , P. C. Dedon

This study identifies DNA damage patterns across tissues and sexes in rodents and humans, revealing age- and sex-dependent variations in DNA adducts and their potential as disease markers.

bioRxiv · Nov 28, 2022 · PreprintBiochemistry

TRAF2, an innate immune sensor, reciprocally regulates mitophagy and inflammation to maintain cardiac myocyte homeostasis.

X. Ma, D. R. Rawnsley, A. Kovacs, M. Islam, J. T. Murphy, C. Zhao, M. Kumari, L. M. Foroughi, H. Liu, K. Hyrc, S. Evans, B. A. French, K. B. Margulies, A. Javaheri, B. Razani, , A. Diwan

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

bioRxiv · Jun 12, 2021Cell Biology

Apolipoprotein M attenuates anthracycline cardiotoxicity and lysosomal injury

Z. Guo, C. Valenzuela Ripoll, A. Picataggi, D. R. Rawnsley, M. Ozcan, J. A. Chirinos, E. Chendamarai, A. Girardi, T. Riehl, H. Evie, A. Diab, A. Kovacs, K. Hyrc, X. Ma, A. Asnani, , A. Javaheri

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

bioRxiv · Jan 12, 2021Pharmacology & Toxicology

Microtubules provide a viscoelastic resistance to myocyte motion.

M. A. Caporizzo, C. Y. Chen, A. K. Salomon, K. Bedi, K. B. Margulies, B. Prosser

This study investigates the mechanical role of microtubules in myocytes, finding they provide viscoelastic resistance that affects contraction and relaxation.

bioRxiv · Jul 3, 2018Biophysics