Author

A. B. Muir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

M. A. Ruffner· 3 shared J. X. Wang· 2 shared K. A. Whelan· 2 shared K. E. Hamilton· 2 shared M. C. Carroll· 2 shared A. D. Fuller· 1 shared A. Klein-Szanto· 1 shared A. Klochkova· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

M. A. Ruffner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.

M. Lal, C. M. Burk, R. Gautam, Z. Mrozek, T. Trachsel, J. T. Beers, M. C. Carroll, D. M. Morgan, A. B. Muir, W. G. Shreffler, M. A. Ruffner

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.

bioRxiv · Jan 26, 2024 · PreprintImmunology

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

M. Sasaki, T. Hara, J. X. Wang, Y. Zhou, K. V. Kennedy, N. N. Umeweni, M. A. Alston, Z. C. Spergel, R. Nakagawa, E. A. McMillan, K. A. Whelan, T. A. Karakasheva, K. E. Hamilton, M. A. Ruffner, A. B. Muir

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2024Peer-reviewedCell Biology

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

A. Klochkova, A. L. Karami, A. D. Fuller, L. R. Parham, S. R. Panchani, S. Natarajan, J. L. Jackson, A. Mu, Y. Tan, K. Q. Cai, A. Klein-Szanto, A. B. Muir, M.-P. Tetreault, K. E. Hamilton, K. A. Whelan

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

bioRxiv · Sep 20, 2023 · PreprintPhysiology

Toll-like receptor 2 stimulation augments esophageal epithelial barrier integrity

M. A. Ruffner, L. Song, K. Mauerer, L. Shi, M. C. Carroll, J. X. Wang, A. B. Muir, J. M. Spergel, K. E. Sullivan

This study shows that TLR2 stimulation enhances esophageal epithelial barrier function by increasing tight junction protein expression and altering chromatin structure.

bioRxiv · Feb 3, 2019Immunology