P. P. Chapagain

Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles

This study shows that minor electrostatic changes in VP40 significantly affect membrane binding, assembly, and budding of Ebola virus-like particles.

Significance of the RBD mutations in the SARS-CoV-2 Omicron: from spike opening to antibody escape and cell attachment

This study computationally examines how Omicron's RBD mutations affect its structure, ACE2 binding, and antibody evasion, suggesting enhanced infectivity and immune escape.

A dual-receptor mechanism between integrins and ACE2 widens SARS-CoV-2 tissue tropism

The paper investigates a dual-receptor mechanism involving integrins and ACE2 for SARS-CoV-2 entry and signaling, highlighting integrin's role in expanding tissue tropism and inflammation.

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

Mutation-induced Changes in the Receptor-binding Interface of the SARS-CoV-2 Delta Variant B.1.617.2 and Implications for Immune Evasion

The paper examines structural changes in the Delta variant's receptor-binding interface and their impact on immune evasion by neutralizing antibodies.

Lipid-specific protein oligomerization is regulated by two interfaces in Marburg virus matrix protein VP40

This study identifies two distinct oligomerization interfaces in Marburg virus VP40 that regulate lipid-specific protein oligomerization and matrix assembly at the plasma membrane.

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection

This paper explores ATN-161 as a potential therapy for SARS-CoV-2 by targeting the interaction between the spike protein and 5β1 integrin, alongside ACE2.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.