Author

K. M. Neugebauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Bewersdorf· 3 shared N. Neuenkirchen· 3 shared A. E. S. Barentine· 2 shared A. K. Gupta· 2 shared H. Lin· 2 shared J. T. Zimmer· 2 shared M. D. Simon· 2 shared M. M. Pillai· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

J. Bewersdorf

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

P. C. Boddu, A. K. Gupta, R. Roy, B. De La Pena Avalos, A. Olazabal Herrero, N. Neuenkirchen, J. T. Zimmer, N. S. Chandhok, D. King, Y. Nannya, S. Ogawa, H. Lin, M. D. Simon, E. Dray, G. Kupfer, , M. M. Pillai

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

bioRxiv · Feb 25, 2023Cancer Biology

An Integrated Platform for High-Throughput Nanoscopy

A. E. S. Barentine, Y. Lin, E. M. Courvan, P. Kidd, M. Liu, L. Balduf, T. Phan, F. Rivera-Molina, M. R. Grace, Z. Marin, M. Lessard, J. Rios-Chen, S. Wang, K. M. Neugebauer, J. Bewersdorf, D. Baddeley

This paper presents an integrated platform for high-throughput single-molecule localization microscopy (SMLM) that enables imaging of 10,000 cells per day.

bioRxiv · Apr 20, 2022Biophysics

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies

G. Biancon, P. Joshi, J. T. Zimmer, T. Hunck, Y. Gao, M. D. Lessard, E. Courchaine, A. E. Barentine, M. Machyna, V. Botti, A. Qin, R. Gbyli, A. Patel, Y. Song, L. Kiefer, , S. Halene

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

bioRxiv · Apr 22, 2021Cancer Biology

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

S. Karmakar, O. Ramirez, K. V. Paul, A. K. Gupta, V. Botti, I. R. d. l. Mozos, N. Neuenkirchen, R. J. Ross, K. M. Neugebauer, M. M. Pillai

The paper identifies EIF3A as a direct target of MSI2 and shows that MSI2 represses EIF3A translation, which amplifies its effects on the proteome.

bioRxiv · Feb 6, 2021Cancer Biology

DMA-tudor interaction modules control the specificity of in vivo condensates

E. M. Courchaine, A. E. S. Barentine, K. Straube, J. Bewersdorf, K. M. Neugebauer

The paper shows that DMA-tudor interactions drive the formation of specific membraneless organelles by controlling condensate assembly and composition.

bioRxiv · Sep 15, 2020Biochemistry