Translational control of breast cancer plasticity
M. Jewer, L. Lee, G. Zhang, J. Liu, S. D. Findlay, K. M. Vincent, K. Tandoc, D. Dieters-Castator, D. F. Quail, I. Dutta, M. Coatham, Z. Xu, B.-J. Guan, M. Hatzoglou, A. Brumwell, , L.-M. Postovit
The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.
bioRxiv · Apr 2, 2019Cancer Biology