T. M. Franzmann

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

Single-molecule digital sizing of proteins in solution

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

Quantifying collective interactions in biomolecular phase separation

This study quantifies collective interactions in biomolecular phase separation by analyzing dilute phase concentrations and free energy, revealing how salts and small molecules modulate condensate formation.

A conserved and tunable mechanism for the temperature-controlled condensation of the translation factor Ded1p

The paper investigates how Ded1p translation factors assemble into condensates in response to heat across fungi, identifying structural and amino acid determinants of temperature sensitivity.

Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.

High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

This paper introduces a microdroplet platform to rapidly generate high-resolution phase diagrams of biomolecular condensates and demonstrates its application in studying phase transitions.

Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells

This study shows that eIF2B filament formation in starved yeast cells regulates translation by acidification-induced assembly, independent of Gcn2 kinase, promoting stress survival and recovery.

Intracellular mass density increase is accompanying but not sufficient for stiffening and growth arrest of yeast cells

The paper shows that increased intracellular mass density correlates with stiffness in yeast cells during metabolic arrest but is not sufficient for growth arrest.