K. Umezawa

Antimicrobial activity of the BAM complex-targeting peptides against multidrug-resistant gram-negative bacteria

This paper demonstrates that BAM complex-targeting peptides, particularly dimeric forms, exhibit bactericidal activity against multidrug-resistant P. aeruginosa and A. baumannii.

Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation

This paper develops a 12-base myogenetic oligodeoxynucleotide that maintains the myogenic activity of a longer sequence while improving drug efficacy and synthesis cost.

Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells

This study shows that the myogenetic oligodeoxynucleotide iSN04 induces cardiomyocyte differentiation from murine pluripotent stem cells by modulating Wnt signaling and inhibiting nucleolin.

Genistein enhances NAD+ biosynthesis by binding to Prohibitin 1 and upregulating nicotinamide phosphoribosyltransferase in adipocytes

This study shows genistein increases NAD+ biosynthesis in adipocytes by upregulating NAMPT through PHB1 binding and stabilization of CCAAT/enhancer-binding protein β.

Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner

The paper identifies an ODN, iSN40, that promotes osteoblast differentiation and calcification without relying on TLR9.

Myogenetic oligodeoxynucleotide (myoDN) complexed with berberine promotes differentiation of chicken skeletal muscle myoblasts

This study shows that myogenetic oligodeoxynucleotides (myoDNs) enhance chicken myoblast differentiation, with the iSN04-berberine complex showing increased activity in myotube formation and myogenic gene expression.

Rapid profiling of drug-resistant bacteria using DNA-binding dyes and a nanopore-based DNA sequencer

This study develops a method to rapidly profile drug-resistant bacteria using DNA-binding dyes and nanopore sequencing.

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin

The paper identifies bacterial-derived oligodeoxynucleotides (myoDNs) that promote skeletal muscle myoblast differentiation by targeting nucleolin.