T. Takaya

Myogenic anti-nucleolin aptamer iSN04 inhibits proliferation and promotes differentiation of vascular smooth muscle cells

The paper shows that the anti-nucleolin aptamer iSN04 inhibits vascular smooth muscle cell proliferation and promotes differentiation, suggesting it as a potential therapy for vascular disease.

Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation

This paper develops a 12-base myogenetic oligodeoxynucleotide that maintains the myogenic activity of a longer sequence while improving drug efficacy and synthesis cost.

Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells

This study shows that the myogenetic oligodeoxynucleotide iSN04 induces cardiomyocyte differentiation from murine pluripotent stem cells by modulating Wnt signaling and inhibiting nucleolin.

Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in myoblasts by modulating the β-catenin/NF-κB signaling pathway

This study shows that iSN04, an anti-nucleolin aptamer, reduces inflammation in myoblasts by inhibiting the β-catenin/NF-κB pathway.

Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner

The paper identifies an ODN, iSN40, that promotes osteoblast differentiation and calcification without relying on TLR9.

Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium

This study shows that the oligodeoxynucleotide iSN04 restores myoblast differentiation and reverses inflammation caused by cancer-conditioned medium.

Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells

This study shows that anti-nucleolin aptamers iSN04 and AS1411 inhibit the growth of embryonal rhabdomyosarcoma cells by targeting nucleolin expression.

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus

This study shows that myogenetic oligodeoxynucleotides (myoDNs) can restore myoblast differentiation in diabetes mellitus patients by reducing myostatin and interleukin-8.

Myogenetic oligodeoxynucleotide (myoDN) complexed with berberine promotes differentiation of chicken skeletal muscle myoblasts

This study shows that myogenetic oligodeoxynucleotides (myoDNs) enhance chicken myoblast differentiation, with the iSN04-berberine complex showing increased activity in myotube formation and myogenic gene expression.

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin

The paper identifies bacterial-derived oligodeoxynucleotides (myoDNs) that promote skeletal muscle myoblast differentiation by targeting nucleolin.