Author

K.-H. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:development & morphogenesis· 3 Organism:human· 3 Organism:plant (other)· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

N. J. Krogan· 3 shared A. L. Richards· 2 shared D. L. Swaney· 2 shared D. Wu· 2 shared J. R. Pannell· 2 shared M. Bouhaddou· 2 shared A. Choudhury· 1 shared A. Dasgupta· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

N. J. Krogan

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Author profile →

8 papers

Recent·Most cited

Effects of floral sex allocation and phenology on the within-flower selfing rate and female reproductive success in Pulsatilla alpina, a perennial herb with strong inbreeding depression

K.-H. Chen, J. R. Pannell

The paper measures within-flower selfing rates and inbreeding depression in Pulsatilla alpina, showing their dependence on floral traits and phenology, and how they affect selection on those traits.

bioRxiv · May 12, 2024Evolutionary Biology

Contrasting Phyllosphere Mycobiome in two Lycopodiaceae Plant Species: Unraveling Potential HupA-Producing Fungi and Fungal Interactions

L. Lin, C. Li, C.-C. Chang, R. Du, J. Ji, L.-Y. Kuo, L. Wang, K.-H. Chen

This study compares the mycobiome of two Lycopodiaceae species, identifying potential HupA-producing fungi and their interactions in Huperzia asiatica.

bioRxiv · Jan 18, 2024Microbiology

Epigenetic reprogramming shapes the cellular landscape of schwannoma

S. J. Liu, T. Casey-Clyde, N. W. Cho, J. Swinderman, M. Pekmezci, M. C. Dougherty, K. Foster, W. C. Chen, J. E. Villanueva-Meyer, D. L. Swaney, H. N. Vasudevan, A. Choudhury, J. D. Breshears, U. E. Lang, C. D. Eaton, , D. R. Raleigh

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Nature Communications · Jan 12, 2024Peer-reviewedCancer Biology

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

D. Wu, R. D. Jansen-van Vuuren, A. Dasgupta, R. Al-Qazazi, K.-H. Chen, A. Y. Martin, J. D. Mewburn, E. Alizadeh, P. D. Lima, O. Jones, P. C. Colpman, N. M. Breault, I. M. Emon, L. Jedlovcnik, Y. Y. Zhao, , S. L. Archer

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

bioRxiv · Dec 21, 2023 · PreprintPharmacology & Toxicology

Size-dependent sex allocation and the expression of andromonoecy in a protogynous perennial herb: both size and timing matter

K.-H. Chen, J. R. Pannell

The study examines size-dependent sex allocation and andromonoecy in Pulsatilla alpina, finding that small plants produce only male flowers, while both small and larger plants allocate to male functions early in the flowering season when mating opportunities are high.

bioRxiv · Mar 10, 2023Evolutionary Biology

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

M. Gupta, C. M. Azumaya, M. Moritz, S. Pourmal, A. Diallo, G. E. Merz, G. M. Jang, M. Bouhaddou, A. Fossati, A. F. Brilot, D. Diwanji, E. Hernandez, N. Herrera, H. T. Kratochvil, V. L. Lam, , K. I Pawar

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

bioRxiv · May 10, 2021 · PreprintBiophysics

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology