Kaixiong Ye

A variance QTL approach to uncover gene-fish oil supplement interaction loci for 14 circulating unsaturated fatty acid traits

Assembly of a high-quality reference genome for the rat tapeworm Hymenolepis diminuta

The paper presents a high-quality reference genome for Hymenolepis diminuta using PacBio HiFi long-read sequencing, achieving high contiguity and completeness.

Gene-diet interaction analysis in UK Biobank identified genetic loci that modify the association between fish oil supplementation and the incidence of dementia

The paper identifies 43 genetic loci that modify the effect of fish oil supplementation on dementia risk using UK Biobank data.

Genome-wide association studies and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating polyunsaturated, monounsaturated, and saturated fatty acids

The paper identifies novel genetic loci for circulating fatty acids and reveals their molecular mechanisms through GWAS and multi-omics integration.

A multi-level gene-diet interaction analysis of fish oil supplementation and 14 circulating polyunsaturated fatty acids-related traits identifies the FADS and GRP12 loci

The paper identifies gene-diet interactions for fish oil supplementation and PUFA levels using GWIS in UK Biobank data, finding significant loci around FADS and GRP12.

The main duct of von Ebner's glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections

Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders

The paper examines the shared genetic basis between polyunsaturated fatty acids and brain disorders using genome-wide association data and identifies causal relationships and shared variants.

Evolution of a chordate-specific mechanism for myoblast fusion

The paper investigates the evolutionary origins of myoblast fusion mechanisms in chordates, identifying the emergence of Myomaker and Myomixer and their roles in muscle development across species.

Altered blood cell traits underlie a major genetic locus of severe COVID-19

The paper identifies blood cell traits associated with the 3p21.31 genetic locus linked to severe COVID-19 and shows their connection to candidate gene expression.

The Causal Effects of Blood Iron and Copper on Lipid Metabolism Disease: Evidence from Phenome-wide Mendelian Randomization Study

This study uses Mendelian randomization to show higher blood iron and copper levels are associated with lower risks of lipid metabolism disorders and related conditions.

Admixture-enabled selection for rapid adaptive evolution in the Americas

The paper identifies admixture-enabled selection in Latin American populations, finding evidence of African ancestry enrichment at immune-related loci and polygenic selection for traits related to immunity and inflammation.

Dietary adaptation of FADS genes in Europe varied across time and geography

The paper shows that positive selection on FADS genes in Europe occurred before and after farming, with geographic variation and associations with lipid levels and disease risk.

Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid

The paper identifies a regulatory insertion-deletion polymorphism in FADS2 associated with increased arachidonic acid synthesis in individuals with a plant-based diet.