Extracellular matrix proteolysis maintains synapse plasticity during brain development
Haruna Nakajo, Ran Cao, Supriya A. Mula, Justin McKetney, Nicholas J. Silva, Kathy H. Li, Robert J. Chalkley, Lisa K. Randolph, Muskaan Shah, Indigo V.L. Rose, Martin Kampmann, Danielle L. Swaney, Christoph Kirst, Anna Victoria Molofsky
The paper shows ECM proteolysis, specifically via MMP14 and brevican, maintains dynamic synapse plasticity during brain development in zebrafish and human iPSC-derived cultures.
Nature Neuroscience · Dec 22, 2025Peer-reviewedNeuroscience