Author

D. Kaushal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Organism:non-human primate· 5 Research Focus:cell type annotation· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2

Frequent Co-Authors

M. Ahmed· 3 shared S. A. Khader· 3 shared A. Swain· 2 shared B. A. Rosa· 2 shared B. Singh· 2 shared D. K. Singh· 2 shared E. Esaulova· 2 shared J. Cole· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

M. Ahmed

Mutual co-authors in cluster

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11 papers

Recent·Most cited

Imaging Architecture of Granulomas Induced by Mycobacterium tuberculosis Infections with Single-Molecule FISH

R. Kumar, A. Kolloli, S. Subbian, D. Kaushal, L. Shi, S. Tyagi

The paper develops a method to image mRNA and protein markers in tuberculosis granulomas using smFISH derivatives, enabling classification of immune cell subtypes and their spatial distribution.

bioRxiv · Feb 2, 2023 · PreprintImmunology

In vivo serial passaging of human-simian immunodeficiency virus clones identifies viral characteristics that enhance persistent viral replication

R. Thippeshappa, P. Polacino, S. S. Chandrasekar, K. Truong, A. Misra, S.-L. Hu, D. Kaushal, J. T. Kimata

The paper identifies viral characteristics that enhance persistent replication in pigtailed macaques by serial passaging of HSIV-vif clones.

bioRxiv · Sep 15, 2021Microbiology

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

D. K. Singh, E. Aladyeva, S. Das, B. Singh, E. Esaulova, A. Swain, M. Ahmed, J. Cole, C. Moodley, S. Mehra, L. Schlesinger, M. Artyomov, S. A. Khader, D. Kaushal

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

bioRxiv · Jun 28, 2021Immunology

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

S. Das, N. D. Marin, E. Esaulova, M. Ahmed, A. Swain, B. A. Rosa, M. Mitreva, J. Rangel-Moreno, M. Netea, L. B. Barreiro, M. Divangahi, M. Artyomov, D. Kaushal, S. A. Khader

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

bioRxiv · Jun 3, 2021Immunology

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

E. B. Irvine, A. O'Neil, P. A. Darrah, S. Shin, A. Choudhary, W. Li, W. Honnen, S. Mehra, D. Kaushal, H. P. Gideon, J. L. Flynn, M. Roederer, R. A. Seder, A. Pinter, S. Fortune, G. Alter

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

bioRxiv · May 6, 2021Immunology

Particle Dynamics and Bioaerosol Viability of Aerosolized BCG Vaccine Using Jet and Vibrating Mesh Clinical Nebulizers

R. K. Redmann, D. Kaushal, N. A. Golden, B. M. Threeton, S. Z. Killeen, P. Kuehl, C. J. ROY

This paper evaluates four nebulizers for aerosolizing BCG vaccine, finding that vibrating mesh devices maintain stable viability across inoculum concentrations, while jet nebulizers show reduced efficiency at higher concentrations.

bioRxiv · Apr 26, 2021Biophysics

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

B. A. Rosa, M. Ahmed, D. K. Singh, J. A. Choreno-Parra, J. Cole, L. A. Jimenez-Alvarez, T. S. Rodriguez-Reyna, B. Singh, O. Golzalez, R. Carrion, L. S. Schlesinger, J. Martin, J. Zuniga, M. Mitreva, S. A. Khader, D. Kaushal

This study identifies transcriptional signatures of IFN signaling and neutrophil degranulation in SARS-CoV-2 infected rhesus macaques and humans, highlighting age-related differences and shared pathways with tuberculosis.

bioRxiv · Aug 6, 2020Immunology

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

F. Oladunni, J.-G. Park, P. Pino Tamayo, O. Gonzalez, A. Ahkter, A. Allue Guardia, A. Olmo-Fontanez, S. Gautam, A. Garcia Vilanova, C. Ye, K. Chiem, C. Headley, V. Dwivedi, L. Parodi, K. Alfson, , J. B. Torrelles

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

bioRxiv · Jul 18, 2020Microbiology

Control of Mycobacterium tuberculosis Infection in Lungs is Associated with Recruitment of Antigen-Specific Th1 and Th17 cells Co-expressing CXCR3 and CCR6.

U. Shanmugasundaram, A. N. Bucsan, S. R. Ganatra, C. Ibegbu, M. Quezada, R. V. Blair, X. Alvarez, V. Velu, D. Kaushal, J. Rengarajan

This study identifies that Mtb-specific Th1 and Th17 cells co-expressing CXCR3 and CCR6 are critical for immune control in lung compartments during asymptomatic TB infection.

bioRxiv · Mar 9, 2020Immunology

ClgR contributes to pulmonary pathology but not bacterial growth in Mycobacterium tuberculosis infection

U. S. Gautam, D. Kaushal

This study shows that ClgR is necessary for Mycobacterium tuberculosis to cause pulmonary pathology but not for bacterial growth in mouse lungs or macrophages.

bioRxiv · Feb 4, 2020 · PreprintMicrobiology

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

C. Verollet, M. Dupont, S. Souriant, L. Balboa, T. Phong, K. Pingris, S. Rousset, C. Cougoule, Y. Romboust, R. Poincloux, M. Ben Neji, C. Allers, D. Kaushal, M. J. Kuroda, S. Benet, , G. Lugo-Villarino

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

bioRxiv · Nov 12, 2019Cell Biology