Author

D. Hardy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 3 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Approach:deep learning· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2

Frequent Co-Authors

A. Brace· 3 shared A. Noirat· 3 shared A. Trifan· 3 shared B. Vesin· 3 shared F. ANNA· 3 shared F. Guinet· 3 shared H. Ma· 3 shared J. Phillips· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

A. Brace

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A recombinant CHIKV-NLuc virus identifies chondrocytes as target of Chikungunya virus in a immunocompetent mouse model

V. Legros, E. Belarbi, p. Jeannin, B. Kuemmerer, D. Hardy, P. Despres, A. Gessain, P. Roques, P.-E. Ceccaldi, V. Choumet

This study uses a recombinant CHIKV-NLuc virus in a mouse model to show CHIKV infects chondrocytes, leading to apoptosis and inflammation in joints, contributing to chronic arthritis.

bioRxiv · May 20, 2024 · PreprintMicrobiology

An oxadiazole-based compound potentiates anti- tuberculosis treatment by increasing host resistance via zinc poisoning

A. Maure, E. Lawaree, F. Fiorentino, A. Pawlik, S. Gona, A. Giraud-Gatineau, M. J. G. Eldridge, A. Danckaert, D. Hardy, W. Frigui, C. Keck, N. Aulner, A. Mai, M. Hamon, L. B. Barreiro, , L. Tailleux

The paper identifies oxadiazole-based compounds that enhance anti-tuberculosis treatment by increasing host resistance through zinc poisoning of Mycobacterium tuberculosis.

bioRxiv · Jul 21, 2023 · PreprintMicrobiology

Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron Replication

F. Le Chevalier, P. Authie, S. Chardenoux, M. Bourgine, B. Vesin, D. Cussigh, Y. Sassier, I. Fert, A. Noirat, K. Nemirov, F. ANNA, M. BERARD, F. Guinet, D. Hardy, P. Charneau, , L. MAJLESSI

This paper develops hACE2 transgenic mice with high permissiveness to SARS-CoV-2 Omicron replication and uses them to test a vaccine candidate.

bioRxiv · Dec 1, 2022 · PreprintMicrobiology

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

B. Henry, G. Volle, H. Akpovi, L. Gineau, C. Roussel, P. A. Ndour, F. Tossou, F. Suarez, F. Palstra, A. Fricot, C. Chambrion, J. Solinc, J. Nguyen, M. Gare, F. Aussenac, , P. Buffet

The paper identifies a genetic mechanism in Fulani individuals that enhances splenic clearance of rigid erythrocytes, contributing to splenomegaly and partial malaria resistance.

bioRxiv · Mar 21, 2022Physiology

An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

B. Vesin, J. Lopez, A. Noirat, P. Authie, I. Fert, F. Le Chevalier, F. Moncoq, K. Nemirov, C. Blanc, C. Planchais, H. Mouquet, F. Guinet, D. Hardy, C. Gerke, F. Anna, , P. Charneau

This study shows an intranasal lentiviral booster enhances and broadens immune response to SARS-CoV-2 variants and improves waning mRNA vaccine immunity in the lungs.

bioRxiv · Jan 30, 2022 · PreprintImmunology

#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol

A. Dommer, L. Casalino, F. Kearns, M. Rosenfeld, N. Wauer, S.-H. Ahn, J. Russo, S. Oliveira, C. Morris, A. Bogetti, A. Trifan, A. Brace, T. Sztain, A. Clyde, H. Ma, , Muholland

This paper uses AI-enabled multiscale computational microscopy to study SARS-CoV-2 Delta variant in respiratory aerosols, revealing atomic-level insights into airborne transmission.

bioRxiv · Nov 12, 2021Biophysics

Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action

A. Trifan, D. Gorgun, Z. Li, A. Brace, M. Zvyagin, H. Ma, A. R. Clyde, D. A. Clark, M. Salim, D. Hardy, T. Burnley, L. Huang, J. McCalpin, M. Emani, H. Yoo, , A. Ramanathan

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

bioRxiv · Oct 9, 2021 · PreprintBiophysics

Full Brain and Lung Prophylaxis against SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Mouse Model or Golden Hamsters

M.-W. Ku, P. Authie, M. Bourgine, F. Anna, A. Noirat, F. Moncoq, B. Vesin, F. Nevo, J. Lopez, P. Souque, C. Blanc, S. Chardenoux, I. Lafosse, D. Hardy, K. Nemirov, , P. Charneau

This study shows that an intranasal lentiviral vaccine protects both the respiratory and central nervous systems against SARS-CoV-2 in a new hACE2 transgenic mouse model.

bioRxiv · Feb 3, 2021 · PreprintMicrobiology

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

L. Casalino, A. C. Dommer, Z. Gaieb, E. P. Barros, T. Sztain, S.-H. Ahn, A. Trifan, A. Brace, H. Ma, H. Lee, M. Turilli, A. Bogetti, S. Khalid, L. Chong, C. Simmerling, , R. E. Amaro

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

bioRxiv · Nov 19, 2020Biophysics