L. Cheng

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study examines how varying levels of dietary NFC/NDF affect rumen microbiomes in Karakul sheep over four periods, finding reduced ruminal pH and bacterial counts with higher NFC/NDF, but no significant changes in dominant bacterial phyla or genera.

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.

The paper reports the complete genome sequence of a novel BPV type 15 strain from a cow in southern Xinjiang and places it phylogenetically within the Xipapillomavirus genus.

This study tracks stem cell-derived extracellular vesicles using MRI to show their selective accumulation at injury sites and protective effects in kidney injury models.

This study identifies the key interaction region and phosphorylation site of EcaICE1 that mediates its interaction with EcaHOS1 in Eucalyptus.

This study identifies the transcription activation domain and interaction region of EcaICE1 with EcaSIZ1 in Eucalyptus camaldulensis, revealing potential SUMOylation pathway similarities to Arabidopsis thaliana.

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

This study identifies GT198 mutations in stromal cells as a common cause of prostate and bladder cancers and suggests GT198 as a therapeutic target.

This study identifies the cotranscriptional folding pathway and regulatory mechanism of the Clostridium beijerinckii pfl riboswitch in response to ZMP.

This study shows that H3K27me3 silencing of WT1 supports DIPG cell proliferation, despite global H3K27me3 loss due to H3.3K27M mutation.