Author

L. G. Griffith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. L. Trumper· 4 shared T. Kassis· 4 shared V. Hernandez-Gordillo· 4 shared G. Eng· 2 shared J. S. Gnecco· 2 shared K. Schneider· 2 shared L. R. Soenksen· 2 shared O. Yilmaz· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBioengineering

D. L. Trumper

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Organoid co-culture model of the cycling human endometrium in a fully-defined syntheticextracellular matrix reveals epithelial-stromal crosstalk

J. S. Gnecco, A. T. Brown, K. Buttrey, C. S. Ives, B. A. Goods, L. Baugh, V. Hernandez-Gordillo, M. Loring, K. Isaacson, L. G. Griffith

This paper develops a synthetic extracellular matrix to model the human endometrium's cyclic changes, revealing epithelial-stromal interactions in health and disease.

bioRxiv · Sep 30, 2021 · PreprintBioengineering

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

J. Zhang, Y. Huang, J.-Y. Yoon, J. Kemmitt, C. Wright, K. Schneider, P. Sphabmixay, V. Hernandez-Gordillo, S. J. Holcomb, B. M. Bhushan, G. Rohatgi, K. Benton, D. Carpenter, J. Kester, G. Eng, , L. G. Griffith

This study develops a co-culture platform to study interactions between human colonic mucosal barriers and Faecalibacterium prausnitzii, showing anti-inflammatory effects and butyrate's role in modulating TLR3/4.

bioRxiv · Jul 2, 2020Bioengineering

Niche-inspired synthetic matrices for epithelial organoid culture

V. Hernandez-Gordillo, T. Kassis, A. Lampejo, G. Choi, M. E. Gamboa, J. S. Gnecco, D. Breault, R. Carrier, L. G. Griffith

This study develops synthetic matrices that support human organoid growth by mimicking the niche environment, showing that local biophysical cues, not bulk properties, drive organoid formation.

bioRxiv · Oct 16, 2019Bioengineering

Gut-Liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids

M. Trapecar, C. Communal, J. Velazquez, C. A. Maass, Y.-J. Huang, K. Schneider, C. W. Wright, G. Eng, O. Yilmaz, D. L. Trumper, L. G. Griffith

The paper uses human physiomimetic systems to show short-chain fatty acids can both improve and worsen ulcerative colitis depending on CD4 T cell activation state.

bioRxiv · Aug 28, 2019Bioengineering

Application of a gut-immune co-culture system for the study of N-glycan-dependent host-pathogen interactions of Campylobacter jejuni

C. Y. Zamora, E. M. Ward, J. C. Kester, W. L. K. Chen, J. G. Velazquez, L. G. Griffith, B. Imperiali

The paper uses a gut-immune co-culture model to study how N-glycan-dependent glycosylation affects Campylobacter jejuni's ability to adhere, invade, and modulate immune responses in intestinal cells.

bioRxiv · Jul 13, 2019Microbiology

OrgaQuant: Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks

T. Kassis, V. Hernandez-Gordillo, R. Langer, L. G. Griffith

OrgaQuant is a deep learning tool that automatically locates and quantifies intestinal organoids in brightfield images using a dataset of manually annotated images.

bioRxiv · Oct 8, 2018Bioengineering

PiFlow: A Biocompatible Low-Cost Programmable Dynamic Flow Pumping System Utilizing a Raspberry Pi Zero and Commercial Piezoelectric Pumps

T. Kassis, P. M. Perez, C. J. W. Yang, L. R. Soenksen, D. L. Trumper, L. G. Griffith

The paper introduces a low-cost, programmable flow pumping system using a Raspberry Pi Zero and piezoelectric pumps to mimic physiological fluid dynamics in cell culture systems.

bioRxiv · Apr 25, 2018Bioengineering

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

L. R. Soenksen, T. Kassis, M. Noh, L. G. Griffith, D. L. Trumper

This paper develops a capacitive sensor and control system for precise, non-contact fluid height monitoring in microfluidic reservoirs, enabling closed-loop feedback control with submillimeter resolution.

bioRxiv · Jan 12, 2018Bioengineering