Author

L. G. Martelotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. C. Lewis· 1 shared A. E. Tron· 1 shared A. E. Williamson· 1 shared A. F. Vallejo· 1 shared A. J. Rogers· 1 shared A. Long· 1 shared A. Misra· 1 shared A. Nguyen· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. C. Lewis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

L. Cooper, H. Xu, J. Polmear, C. Szeto, E. S. Pang, M. Gupta, J. J. Taylor, K. J. L. Jackson, A. Nguyen, N. La Gruta, L. G. Martelotto, I. A. Parish, M. O'Keeffe, C. D. Scharer, S. Gras, K. L. Good-Jacobson

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

bioRxiv · Mar 2, 2023Immunology

snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling

A. F. Vallejo, K. Harvey, T. Wang, K. Wise, L. M. Butler, J. Polo, J. T. Plummer, A. Swarbrick, L. G. Martelotto

This paper introduces snPATHO-Seq, a method for high-quality single nucleus RNA sequencing from FFPE samples, showing improved sensitivity and accuracy compared to existing methods.

bioRxiv · Aug 23, 2022 · PreprintCancer Biology

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

E. Gruber, J. So, A. C. Lewis, R. Franich, R. Cole, L. G. Martelotto, A. J. Rogers, E. Vidacs, P. Fraser, K. Stanley, L. Jones, A. S. Trigos, N. Thio, J. Li, B. Nicolay, , L. M. Kats

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

bioRxiv · Apr 6, 2022Cancer Biology

Discovery of embryonically derived bipotent endothelial-macrophage progenitor cells in postnatal aorta

A. E. Williamson, S. Liyanage, M. Hassanshahi, M. S. I. Dona, D. Toledo-Flores, D. X. A. Tran, C. Dimasi, N. Schwarz, S. Fernando, T. Salagaras, A. Long, J. Kazenwadel, N. L. Harvey, G. R. Drummond, A. Vinh, , P. J. Psaltis

The paper identifies bipotent endothelial-macrophage progenitor cells in mouse aorta that contribute to postnatal vasculogenesis and macrophage formation.

bioRxiv · Oct 18, 2021 · PreprintCell Biology