J. J. Taylor

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

Validation of ligand tetramers for the detection of antigen-specific lymphocytes

The paper validates ligand tetramers for detecting antigen-specific lymphocytes, finding batch-to-batch variability and performance decline in certain fluorochromes.

Cross-Protective Antibodies Against Common Endemic Respiratory Viruses

This study identifies two cross-neutralizing monoclonal antibodies targeting multiple respiratory viruses and validates their efficacy through structural and functional analyses.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection

The paper identifies a monoclonal antibody, PI3-E12, that neutralizes HPIV3 and provides protection in cotton rats, showing potential for clinical use in both immunocompetent and immunocompromised individuals.

B cells engineered to express pathogen-specific antibodies using CRISPR/Cas9 protect against infection

This study uses CRISPR/Cas9 to engineer B cells with pathogen-specific antibodies, providing durable protection against RSV in immunocompromised hosts.

Antigen-specific humoral immune responses by CRISPR/Cas9-edited B cells

CRISPR/Cas9-edited B cells produce broadly neutralizing antibodies against HIV-1 and elicit protective immune responses in vivo.