Author

L.-a. Pirofski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Mengotto· 2 shared C. Florez· 2 shared D. Haslwanter· 2 shared D. Kimmel· 2 shared E. Laudermilch· 2 shared J. Barnhill· 2 shared J. M. Fels· 2 shared J. P. Daily· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Mengotto

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3 papers

Recent·Most cited

Isolation and characterization of human monoclonal antibodies to pneumococcal capsular polysaccharide 3

R. Babb, C. R. Doyle, L.-a. Pirofski

This study isolates and characterizes human monoclonal antibodies against pneumococcal capsular polysaccharide 3, finding that agglutination and opsonophagocytic activity correlate with in vivo efficacy and that light chain variable region mutations affect function.

bioRxiv · Aug 2, 2021Microbiology

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

N. G. Herrera, N. C. Morano, A. Celikgil, G. I. Georgiev, R. J. Malonis, J. H. Lee, K. Tong, O. Vergnolle, A. B. Massimi, L. Y. Yen, A. J. Noble, M. Kopylov, J. B. Bonanno, S. C. Garrett-Thomson, D. B. Hayes, , S. C. Almo

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

bioRxiv · Jun 14, 2020Biochemistry

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

M. E. Dieterle, D. Haslwanter, R. H. Bortz, A. S. Wirchnianski, G. Lasso, O. Vergnolle, S. A. Abbasi, J. M. Fels, E. Laudermilch, C. Florez, A. Mengotto, D. Kimmel, R. J. Malonis, G. Georgiev, J. Quiroz, , R. K. Jangra

This paper develops a recombinant vesicular stomatitis virus expressing SARS-CoV-2 spike protein to assess neutralizing antibodies in convalescent sera and validate its utility for vaccine and therapeutic development.

bioRxiv · May 20, 2020Microbiology